Figure: The functions of Ror2 and IFT20 in invasive cancer cells. In healthy cells IFT20 regulates the formation and function of primary cilia. Many cancer cells lack cilia, and these cells induce and sustain the expression of IFT20 through the high expression of Ror2. IFT20 promotes the formation of Golgi-derived microtubules by binding with the GM130-AKAP450 complex in Golgi. By doing this it regulates the deployment of Golgi and transport of proteins within Golgi, both important parts of the formation of invadopodia.

Paper Information
Paper
“Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness”

Authors
Michiru Nishita1, Seung-Yeol Park2, Tadashi Nishio1, Koki Kamizaki1, ZhiChao Wang1, Kota Tamada3, Toru Takumi3, Ryuju Hashimoto4, Hiroki Otani4, Gregory J. Pazour5, Victor W. Hsu2, Yasuhiro Minami1

1: Division of Cell Physiology, Department of Physiology and Cell Biology, Kobe University, Graduate School of Medicine, Kobe 650-0017, Japan
2: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA,
3: RIKEN Brain Science Institute, Wako 351-0198, Japan,
4: Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo 690-8504, Japan,
5: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA

Journal
Scientific Reports
Related Information

(Graduate School of Medicine, Communications Division)